Post Doctoral Position to develop novel human multicellular 3D CNS models for early drug development (HTB)

Job description

·  Job facts

At Roche, we believe it's urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients' lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

The Postdoctoral position is embedded in a cross-departmental collaboration within pRED in the frame of a Human Translational Bioengineering (HTB) Center of Excellence. As a Postdoctoral Fellow you will pioneer development of human 3D multicellular brain models for modeling of neurodegenerative diseases, drug efficacy and drug safety testing. Novel models should in particular recapitulate key features of myelination and innate immune cell function. We are now looking for a highly motivated and forward-thinking Postdoc to join our team in an excellent and high-reaching scientific environment.

In this position you will:

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landscape existing cerebral-spheroid-models in respect to suitability, reproducibility, complexity and throughput

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Set-up best suited models for characterization in the wet-lab

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Combine these models with myeloid cells derived from iPSC

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Explore defined models for aspects of neurodegeneration and suitability for efficacy and safety testing

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Work in a matrix environment with scientists, postdocs and research associates across different fields of drug development and 3D model systems

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You will gain insights into a variety of aspects of drug discovery and 3D model systems

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You will profit from a well-established network of academic collaboration partners

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Publish your work in peer-reviewed journals and present on international conferences

Who we are

At Roche, 98,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.

Desired profile

Who You Are

You are someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multicultural environment motivates you. As a fast learner you actively drive the quality of the requirements. Moreover you have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate.

You have expertise and are experienced in the following

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Ph.D. or M.D./Ph.D degree in neuroscience, cell biology, bioengineering or related fields

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Strong experience with human cell culture, including stem-cells (iPSC), ideally 3D models and organ-on-a-chip technologies.

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Excellent skills in live-cell imaging, immunostaining, confocal imaging and quantitative image analysis are highly desired.

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Independent research skills such as designing, executing and interpreting experiments, as demonstrated by previous publications.

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Excellent written and oral English skills

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Excellent presentation and communication skills

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Documenting and presentation of research results in internal and external meetings as well as publication in peer reviewed journals.

This is a temporary two-year position with a flexible start date. Please clearly indicate your preferred starting date on your motivation letter. All applications always need to include a CV with publication list, motivation letter and certificate of your PhD.

What we stand for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq

Roche is an equal opportunity employer.
Research & Development, Research & Development > Research

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